Title thesis: Triage of HPV-positive women by methylation marker analysis

De Strooper presents in her thesis work evaluating DNA methylation markers as candidate triage tests for hrHPV-positive women. It elaborates on methylation of the promoter regions of the tumour suppressor genes CADM1, MAL, mir124-2, and FAM19A4, which provide highly appealing disease markers for hrHPV-positive women. The studies described herein could contribute to a more objective manner of cervical cancer screening, both applicable to physician-taken scrapes and self-collected samples. De Strooper used in her research the Cervex-Brush for physician-taken scrapes and both the Delphi-screener as well as Evalyn Brush for self-sampling.